pK Chemicals produces Dextran in various molecular weights supported by the necessary quality assurance and documentation. Our Dextran product range is both available with standard specifications and according to customized specifications. Our products are manufactured in compliance with current Good Manufacturing Practice (cGMP).
Dextran is prepared by fermentation of sugar, harvest and purification followed by cracking and separation into the desired molecular weight. The molecular weight denotation of dextran is the molecular weight in Da divided by 1000. I.e. dextran 40 is dextran 40.000 Da (or 40 kDa). Typical denotations are: 1, 3, 5, 10, 40, 60, 70, 110, 150, 250, 500 and 800.
Dextran is a non-ionic polysaccharide, appearing as a white powder. Dextran is pH-neutral and highly water-soluble, up to 50w/v. It forms clear and stable aqueous solutions, which can be filtered and even sterile filtered. Dextran is also soluble in solvents like methyl sulfide, formamide, ethylene glycol, and glycerol. Dextran fractions are insoluble in simple alcohols, such as methanol, ethanol and isopropanol and most ketones, such as acetone.
Dextran is a polysaccharide. The main chain is formed by 1,6 glycosidic linkages. The side branches are primarily 1,3 linkages and the degree of branching is approximately 5%. The branches are mostly 1-2 glucose units long. The 1,6 glycosidic linkage is formed between a primary hydroxyl group and a secondary hydroxyl group. The much higher flexibility of the primary hydroxyl group is responsible for the high degree of flexibility of the dextran back bone as compared to e.g. cellulose. The flexibility of dextran is responsible for the majority of the highly-desired properties of dextran.
At pK Chemicals we run the entire process right from the start to the final product, which is your security for a high-quality dextran product.
Blood Volume Expander - Provides colloid osmotic pressure
Organ Preservation - Provides colloid osmotic pressure
Thrombosis prophylaxis - Inhibits clot formation
Vaccine Adjuvant - Provides high molecular weight scaffold
Eye care liquids - Lubricant
Cryopreservation - Inhibits crystal formation during freezing
Lyophilization - Stabilization of proteins/enzymes
Drug delivery - Chelation of metal ions and API
Compendial specifications exists for the following Dextran molecular weights in the European Pharmacopoeia - EUP and the US pharmacopoeia - USP:
Dextran 1 EP and USP
Dextran 40 EP and USP
Dextran 60 EP
Dextran 70 EP and USP