CAS Number: 121-75-5
pK Chemicals manufactures Malathion in accordance with current Good Manufacturing Practice (cGMP).
• is used as an API in lice shampoo
• is highly effective, safe, and has been used for decades all over the world
• is approved by FDA and EMEA for treatment of head lice infestation
Malathion, an organophosphate, is both pediculicidal (kills live lice) and partially ovicidal (kills lice eggs). Organophosphates acts by inhibiting the enzyme acethylcholine esterase, which breaks down the neurotransmitter acetylcholine, the primary neurotransmitter in muscle tissue. The accumulation of acetylcholine causes muscle spasms and death of the lice and bugs by suffocation.
The compendial specification for Malathion exists in the European Pharmacopoeia.
|Appearance||Colourless to pale yellow liquid||Visual (Ph.Eur.)|
|Identification||As Malathion CRS||IR (2.2.24)|
|Relative Density||1.220 to 1.240||Relative Density (2.2.5)|
|Optical Rotation||- 0.1 to + 0.1 º||Polarimetry (2.2.7)|
|Water||NMT 0.1 w/w %||Karl Fischer (2.5.12)|
|Assay||98.0 - 102.0 %||HPLC (2.2.29)|
|Impurity A (Isomalathion)||NMT 0.3 w/w %||HPLC (2.2.29)|
|Impurity B (Maloxon)||NMT 0.1 w/w %||HPLC (2.2.29)|
|Impurity C||NMT 0.25 %||HPLC (2.2.29)|
|Any single unspecified impurity||NMT 0.1 %||HPLC (2.2.29)|
|Total impurities||NMT 1 %||HPLC (2.2.29)|
|Ethanol||NMT 5000 ppm||GC (Ph.Eur)|
|TAMC||NMT 1000 Cfu/g||(2.6.12)|
|TYMC||NMT 100 Cfu/g||(2.6.12)|