CAS Number: 9064-91-9
DEAE-Dextran (Di-ethyl-amino-ethyl Dextran) is a polycationic derivative of Dextran. It is a white, hygroscopic powder, freely soluble in water and salt solutions which can be sterilized by autoclaving or by sterile filtration.
DEAE-Dextran maintains its quality and efficacy for more than 3 years when stored at room temperature in airtight packaging. The product is supplied as the hydrochloride.
DEAE-Dextran offers a wide range of chemical and biological properties. The applications below are well documented.
DEAE-dextran is a well-known adjuvant in vaccines.1 The DEAE-dextran will help create a strong immune reaction in the human or animal receiving the vaccine.
DEAE-dextran can be used to transfer nucleic acid into cells. Due to the cationic properties of DEAE-dextran, it will associate tightly with the anionic backbone of the nucleic acid 2,3. This will create a net-positive complex which can adhere to the cell membrane and enter the cytoplasm via endocytosis or an induced osmotic shock.
DEAE-dextran has shown to stabilize both lyophilized proteins and enzyme as well as proteins in solutions4.
Clinical studies of DEAE-dextran have shown that it can reduce both blood cholesterol and triglycerides.4
Studies have shown that DEAE-dextran can increase the infectivity of viruses.5
|Nitrogen content, %N||2.8-3.3||EP|
|Specific optical rotation||+140 to +150||EP|
|Absorbance, (375 nm)||Max 0.1||EP and USP|
|Heavy metals; ug/g||≤ 5||USP|
|Loss on drying, %||≤ 7||EP and USP|
|pH, (1 % w/v sol)||4.0-6.0||EP|
|Residue on ignition; %||≤ 1.0||USP|
|TYMC, cfu/g||≤ 100||EP / USP|
|TAMC, cfu/g||≤ 100||EP / USP|